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Combined activation of GLP-1, GIP, and GCG systems theoretically provides complementary mechanisms: GLP-1-mediated insulin sensitization and satiety promotion, GIP-mediated enhancement of insulin secretion and adipose lipid buffering, and glucagon-mediated direct hepatic lipid oxidation and energy expenditure augmentation

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Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension

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Age Magnifies Sleep Apnea: Each additional year of age increased breathing interruptions by 0.32 events per hour in the mixed-BMI group and by 0.42 events per hour in the obese-only group, showing a greater impact in those with higher BMIs

Vijiaratnam N, Girges C, Auld G, Chau M, Maclagan K, King A, et al